![]() ![]() High‐dose alcohol ≥ 13 hours after consumption (4 RCTs, N = 154) increased SBP by 3.7 mmHg (95% CI 2.3 to 5.1), DBP by 2.4 mmHg (95% CI 0.2 to 4.5), and HR by 2.7 bpm (95% CI 0.8 to 4.6) (moderate‐certainty evidence for all).Īlcohol has a biphasic effect on blood pressure and increases heart rate The certainty of evidence was moderate for SBP and HR, and low for DBP. High‐dose alcohol within 7 to 12 hours of consumption (3 RCTs, N = 54) decreased SBP by 3.7 mmHg (95% CI ‐7.0 to ‐0.5) and DBP by 1.7 mmHg (95% CI –4.6 to 1.8) and increased HR by 6.2 bpm (95% CI 3.0 to 9.3). High‐dose alcohol (> 30 g) within six hours (16 RCTs, N = 418) decreased SBP by 3.5 mmHg (95% CI ‐6.0 to ‐1.0), decreased DBP by 1.9 mmHg (95% CI‐3.9 to 0.04), and increased HR by 5.8 bpm (95% CI 4.0 to 7.5). The certainty of evidence was moderate for SBP and HR, and was low for DBP. Low‐dose alcohol ( 13 hours after consumption (4 RCTs, N = 66) did not affect BP or HR. ![]() The mean age of participants was 33 years, and mean body weight was 78 kilograms. ![]() We included 32 RCTs involving 767 participants. Most of the study participants were male (N = 642) and were healthy.
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